Objective: To determine the prevalence of endocrine disorders among individuals with Down Syndrome in KSA. Methods: This research employs a cross-sectional study design to investigate the prevalence of endocrine disorders among individuals with Down Syndrome in the Kingdom of Saudi Arabia (KSA). A cross-sectional approach allows us to collect data at a single point in time from a diverse group of participants, providing a snapshot of the prevalence and characteristics of endocrine disorders within the study population. Results: The study included 686 participants. The participants asked if they had a child with Down syndrome. Most of them answered no (n= 576, 84%) followed by yes (n= 110, 16%). The most frequent child age who has Down syndrome among study participants was 7-10 years (n= 45, 40.9%) followed by 3-6 years (n= 30, 27.3%). The most frequent child gender who has Down syndrome among study participants was female (n= 57, 51.8%) followed by male (n= 53, 48.2%). Father's educational level among study participants with most of them having a university (n= 82, 74.5%). Mother's educational level among study participants with most of them having a university (n= 77, 70%). Participants were asked if there was a first-degree relationship between the parents. There 55 had a first-degree relationship with (50%), and 55 didn’t have a first-degree relationship between parents with (50%). Participants were asked the female about two diseases polycystic ovary disease there were 12 had it (10.9%), 62 didn’t have it (56.4%), and the second disease was Turner syndrome 22 had it (20%) and 53 participants didn’t have it (47.3%). Conclusion: Study results showed that most of the study participants don’t have Down Syndrome according to the parent's answers. Half of the participants have a first-degree relationship between their parents. The most educational level for parents was the university.