Background: Chronic renal failure is a complicated health disease with considerable consequences for affected people and healthcare systems. Improving awareness and early identification of chronic renal failure requires a better understanding of the knowledge and attitudes of the illness across various demographics. Objective: This study aimed to assess the knowledge and perceptions of chronic renal failure among participants, considering various demographic factors such as gender, marital status, educational level, and working status. Methods: A cross-sectional study was conducted with 407 participants. Data were collected using a structured questionnaire, and associations between demographic factors and knowledge/perceptions of chronic renal failure were analyzed using chi-square tests and p-values. Results: The findings revealed noteworthy variations in knowledge and perception based on demographic factors. Gender differences were observed, with females exhibiting lower awareness of chronic renal failure compared to males. Widowed individuals showed a higher level of confidence in their knowledge. Educational level had a significant influence, with higher education correlating with better knowledge. Employment status also played a role, with non-working individuals showing different beliefs regarding renal failure. Conclusion: This research underlines the necessity of considering demographic variables for addressing knowledge gaps and misunderstandings concerning chronic renal failure. Improved early diagnosis and treatment of this serious health issue may be achieved via the creation of educational interventions and awareness programs that are specifically designed to address the requirements of various demographic groups.