Can prophylactic Dexamethasone play a role in reducing extubation failure?
Rasha Khalid Almubarak, Reem Suleman Alshail, Abdullah khalifah Albahrani, Aseel Essam Alghonimy, Abdulhadi Nasser Alhaiz, Abdulaziz Saud Alaqil
Abstract
Background
Endotracheal intubation is an essential life-saving resuscitative procedure.
Aims
Our research seeks to establish whether the prophylactic use of Dexamethasone before removing a breathing tube is associated with a reduced risk of extubation failure.
Methods
A retrospective observational study was conducted at the Pediatric Intensive Care Unit (PICU) of King Saud Medical City, a tertiary center in Riyadh, Saudi Arabia. Children aged between 0 and 14 years who underwent mechanical ventilation for 48 hours were given Dexamethasone 0.5mg/kg every 6 hours beginning 12-24 hours prior to planned extubation. Patients were monitored for extubation failure and the appearance of stridor.
Results
74 patients enrolled in the study. There was no significant association found between the use of Dexamethasone and prevention failure of extubation with a p-value of 0.8 .
Conclusion
We found that the prophylactic use of Dexamethasone failed to prevent extubation failure.
Full Text:
Endotracheal intubation is an essential life-saving resuscitative procedure.
Aims
Our research seeks to establish whether the prophylactic use of Dexamethasone before removing a breathing tube is associated with a reduced risk of extubation failure.
Methods
A retrospective observational study was conducted at the Pediatric Intensive Care Unit (PICU) of King Saud Medical City, a tertiary center in Riyadh, Saudi Arabia. Children aged between 0 and 14 years who underwent mechanical ventilation for 48 hours were given Dexamethasone 0.5mg/kg every 6 hours beginning 12-24 hours prior to planned extubation. Patients were monitored for extubation failure and the appearance of stridor.
Results
74 patients enrolled in the study. There was no significant association found between the use of Dexamethasone and prevention failure of extubation with a p-value of 0.8 .
Conclusion
We found that the prophylactic use of Dexamethasone failed to prevent extubation failure.
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