This study suggests that new studies are required into the possible relationship between cancer and the rapid up/down-regulation of glucose levels from long term high sugar dietary behaviour. Where there is no outside cancer-causing impact, for example, harmful affront or oxidative pressure, long haul high glucose admission might assume a few parts in malignant growth improvement and metastasis. Additionally, during endoplasmic reticulum (ER) stress conditions the unfurled protein reaction (UPR) flagging might become upset (under-actuated) allowing uncontrolled misfolded proteins adding to conditions for disease inception.. Conversely, UPR signalling may then over-activate hindering immunogenic response to sequester and terminate cancer cells, providing further opportunities in cancer formation.