Objectives: The prevalence of psychiatric conditions among dermatology clinic patients is quite high. This study aims to assess and measure the prevalence of anxiety and depression disorders, and to assess any significant association with clinical, social, and epidemiological variables.

Methods: The study is a cross-sectional study conducted at King Abdulaziz Medical City, Jeddah, Saudi Arabia. Hospital Anxiety and Depression Scale (HADS) was used and delivered to patients attending the dermatology clinic from 2019 to 2020. .

Results:  Out of the total 305 patients, 135 (44.3%) were males and 170 (55.7%) were females. The mean age of this study’s participants was 37.13 ± 15.24. Almost sixteen percent of the patients’ anxiety score was abnormal, and 17.5% of the patients’ depression score was abnormal. Anxiety was significantly associated with both male gender (P= 0.008), and severity of the disease ( P=