Background: Needle stick injury is the most common workplace related health hazards responsible for transmission of blood-borne pathogens. Aims The aim of this study was to assess needle stick injury and associated factors among health professionals in public hospitals in Degahbur & Kebridahar from February to September 2021.

Methods: A facility based cross-sectional study design was conducted From February to August, 2021. A total of 264 health professionals were drawn using simple random sampling technique. Data was collected by using structured self-administered questionnaire. Data analysis was done by using Epi-data version 3.1 then exported to SPSS version 21. Frequencies of variables were generated; tabulation and percentages were used to illustrate study findings. Bivariate and multivariable logistic regression was used to analyse the association between the dependent and independent variables.

Results: The prevalence of needle stick injury among health professionals was 107(40.5%). Male (AOR=4.114 95%CI 1.469-11.522), being single, (AOR=4.919 95%CI 1.695-14.279) and safety box turn out, (AOR=2.906 95%CI 1.154-7.318) were significantly associated with needle stick injury. Conclusion: The prevalence of needle stick injury among health professionals was high in the public hospitals. The government should focus on increasing training to fill the skill gap, apply universal precaution and never recap needles after use and ensure availability of safety box in the workplace to establishing better working environments.