Prevalence and outcome of newly diagnosed diabetes in COVID-19 patients: A systematic review
Abdullah M Alguwaihes
Abstract
BackgroundPatients with COVID-19 with diabetes mellitus (DM) are reportedly more likely to develop severe clinical course and increased mortality.
AimsWe aimed to investigate the prevalence of newly diagnosed DM in COVID-19 patients and observe the association of underlying DM with increasing incidence of serious adverse events and mortality in COVID-19 patients.
Methods We searched PubMed/Medline, Cochrane, Google Scholar, and Embase/Ovid for relevant articles that match our inclusion criteria. We assessed the quality of studies using the National Heart, Lung, and Blood Institute Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Our outcomes of interest were mainly the prevalence of ICU admissions and mortality.
Results The pooled proportion of newly diagnosed DM in hospitalized COVID-19 patients was 44.5 per cent. We report that newly diagnosed diabetics indicate a poor prognosis of COVID-19 compared with non-diabetics or previously-known DM. We also show that COVID-19 patients with newly diagnosed DM are at increased risk of getting ICU admissions compared with patients with pre-existing DM.
ConclusionWe show that 44.5 per cent of hospitalized COVID-19 patients are likely to develop DM. We also confirm that DM worsens the prognosis of COVID-19 patients and raises the incidence rates of both ICU admissions and mortality.
Full Text:
AimsWe aimed to investigate the prevalence of newly diagnosed DM in COVID-19 patients and observe the association of underlying DM with increasing incidence of serious adverse events and mortality in COVID-19 patients.
Methods We searched PubMed/Medline, Cochrane, Google Scholar, and Embase/Ovid for relevant articles that match our inclusion criteria. We assessed the quality of studies using the National Heart, Lung, and Blood Institute Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Our outcomes of interest were mainly the prevalence of ICU admissions and mortality.
Results The pooled proportion of newly diagnosed DM in hospitalized COVID-19 patients was 44.5 per cent. We report that newly diagnosed diabetics indicate a poor prognosis of COVID-19 compared with non-diabetics or previously-known DM. We also show that COVID-19 patients with newly diagnosed DM are at increased risk of getting ICU admissions compared with patients with pre-existing DM.
ConclusionWe show that 44.5 per cent of hospitalized COVID-19 patients are likely to develop DM. We also confirm that DM worsens the prognosis of COVID-19 patients and raises the incidence rates of both ICU admissions and mortality.
PDF