Efficacy of tranexamic acid administration in traumatic brain injury patients: A review
Khaled AbdullahS Alasmari, Lena Defallah G Alzahrani, Abdulrahman Arshed N Alharfy, Aumniyat Saad A Alrashidi, Muath Sulaiman G Alhamdi, Bedour Eid H Alatawi, Faisal Saeed A Alghamdi, Sultan Suliman Q Al-Ruwaili, Amira Abdullah A Alatwi, Adnan Fahad M Soqier, Atheer Abdullah I. Al Jubeiri, Bashaier Musslum M Albalawi, Ahdab Abd Ulsattar M Alsabhi, Ibrahim Mahmoud H Ajwah, Fatimah Ali A Swead, Salem Ahmed S Shaman
Abstract
Background
Anti-fibrinolytic medications decrease traumatic intracranial haemorrhage (ICH). Tranexamic acid (TXA) is an anti-fibrinolytic, which recently has shown effectiveness in management of traumatic haemorrhage.
Aims
To summarize the randomized control trials (RCTs) that evaluate the efficacy of tranexamic acid administration in traumatic brain injury (TBI) patients.
Methods
An electronic literature review, including PubMed, Google Scholar, and EBSCO that examining RCTs, observational, and experimental studies which study the efficacy of TXA administration in (TBI) patients.
Results
The current review included 7 randomized studies reported the efficacy of TXA in management of TBI. TXA limit secondary brain injury by preventing the expansion of ICH. Administration of TXA exhibited a tendency to decrease head trauma-related mortality.
Conclusion
TXA significantly lower the risk of ICU expansion m and prevent brain injury related deaths.
Full Text:
Anti-fibrinolytic medications decrease traumatic intracranial haemorrhage (ICH). Tranexamic acid (TXA) is an anti-fibrinolytic, which recently has shown effectiveness in management of traumatic haemorrhage.
Aims
To summarize the randomized control trials (RCTs) that evaluate the efficacy of tranexamic acid administration in traumatic brain injury (TBI) patients.
Methods
An electronic literature review, including PubMed, Google Scholar, and EBSCO that examining RCTs, observational, and experimental studies which study the efficacy of TXA administration in (TBI) patients.
Results
The current review included 7 randomized studies reported the efficacy of TXA in management of TBI. TXA limit secondary brain injury by preventing the expansion of ICH. Administration of TXA exhibited a tendency to decrease head trauma-related mortality.
Conclusion
TXA significantly lower the risk of ICU expansion m and prevent brain injury related deaths.
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