Strongyloidiasis is an infection caused by the helminthic parasite Strongyloides stercoralis. It is endemic in rural regions of the tropics and subtropics areas. There are between 30 and 100 million an infected persons worldwide. Clinical manifestations of S. stercolaris range from asymptomatic to life-threatening and can be acute or chronic. Symptomatic disease can manifest in skin, the gastrointestinal (GI) tract and/or the respiratory system. Severe and disseminated infection can lead to serious complications. We report a case of strongyloidiasis in a 48-year-old male who presented with gastrointestinal symptoms and developed acute cholecystitis and deep venous thrombosis. Strongyloidiasis is uncommon in Saudi Arabia but must be considered for patients with gastrointestinal symptoms who recently arrived from an endemic area or will begin immunosuppressive therapy.