Chlorhexidine versus Povidone-Iodine for the prevention of ‎Surgical Site ‎Infections: A review.‎

Abdullah Mohammed A Alzahrani, Meshari Ibrahim A Alayshan, Abdullah Alturqi K Alanazi, Ali Nuwaysir S. Alruwaili, Mohammed Amid S Alkhaldi, Amer Abdulaziz H Alharbi, Fahad Hammad F Alrayes, Saleh Abdullah S Almoallem, Mohammed Hamoud E Alkhaldi, Fahad Ghuwayli M Aljabri, Ahmad Saleh A Alrwaili, Alhanouf Abdullah Alatawi, Nawal Ali S Alharthi, Reuof Salem A Alamri, Renad Mohammed H Alanazi, Ibrahim Mahmoud H Ajwah


Surgical Site Infections (SSIs) are the third most frequently reported health care-associated ‎infection‎ and it remain a major clinical problem despite improvements in prevention, as they ‎are associated with ‎significant mortality and morbidity. Prevention strategies for SSIs are based ‎on reducing the risk of infection by bacteria, So many antiseptic agents are ‎used, the most ‎common one are Chlorhexidine and Povidone-Iodine.‎

To discuss the ‎findings of RCTs that compare Chlorhexidine versus Povidone-Iodine in the prevention of ‎Surgical ‎Site ‎Infections (SSIs).‎

This systematic review was carried out, including PubMed, Google Scholar, and EBSCO that ‎examining randomized trials of Chlorhexidine and Povidone-Iodine to summarize the major ‎RCT that compare Chlorhexidine versus Povidone-Iodine in the prevention of Surgical Site ‎Infections (SSIs).‎

The review included six randomized studies that compare between Chlorhexidine and Povidone-‎Iodine for the prevention of SSIs. The findings showed that many studies prefer using ‎Chlorhexidine over Povidine-Iodine to reduce SSIs, few studies prefer using PVI as antiseptic ‎and other studies reported that there is no significant difference between both.

Majority of results prefer using Chlorhexidine than Povidone-Iodine‎ as antiseptics but ‎there were few findings prefer ‎PVI and other studies reported that there was no significant ‎difference between using them as ‎antiseptics.‎
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