Objectives. Depression is a mood-related mental illness that is treated effectively by antidepressants. Most of the public are not aware of the various uses of antidepressants. Antidepressants are associated with controversial addictive false believes. They are also related to social stigma. This study determines the awareness of a representative sample of Imam Abdulrahman bin Faisal university (IAU) students’ regarding the use of antidepressants to treat various diseases. It also evaluates their awareness about the side effects of antidepressants and their association with addiction and social stigma that may collectively lead to refusal of treatment. Methods. A cross-sectional study involving 389 students who completed a 22-item validated questionnaire to measure their degree of awareness regarding uses, side effects and misconceptions related to antidepressants. Results. Among the 389 participants, 196 are females. Only 28.5% and 10.3% were knowledgeable of the uses of antidepressants for other psychiatric and somatic diseases, respectively. Additionally, 47.3% agreed that patients may stop taking antidepressants if they had a previous knowledge of their side effects. Also, 71% of the participants falsely believed that antidepressants cause addiction, and many of them stated that this belief shall not prevent patients from taking medications. Two-third of the participants acknowledged that patients who are on antidepressants are concerned of social stigma, and 95% of them believed this may be a reason for stopping medications. Conclusion. This study concludes that there are alarming misconceptions regarding antidepressants. It also highlights the lack of awareness about uses of antidepressants and encourages further antidepressants’ awareness campaigns.