SCD develops when haemoglobin (HbS) is produced in the body as a result of a mutation occurring in haemoglobin beta chain. SLE is defined as a rare, chronic autoimmune multi-organ manifestation. SCD and SLE rarely coincide in literature due to the limited number of cases and the overlapping of symptoms of both diseases. Majority affecting child bearing age, with a mean of 23-year-old. Articular manifestations like joint pain are common in both diseases. We report a case of female adolescent with sickle cell disease associated with systemic lupus erythematous.