The article discusses the problem of immune response complexity, found in functional unity of regulatory systems, cooperation of immunocompetent cells, connection and regulation of specific and non-specific defence mechanisms, association of immune, routine laboratory and clinical parameters under normal and pathological conditions. The article reviews the influence of disease combinations, their comprehensive treatment on immunopathology, and the corrector effects. To reproduce natural mechanisms of homeostasis regulation, complex, blocking immunotherapy of diseases is suggested.