Sinus histiocytosis with massive lymphadenopathy, (Rosai-Dorfman Disease) with cholastatic jaundice in an HIV positive patient
Kgomo Mpho, Elnagar Ali Ahmed, Mashoshoe Kgataki Sam, Thomas Preetha, Ngwata Portia, Bida Mishack
Abstract
Introduction
Sinus histiocytosis with massive lymphadenopathy is a rare histiocytic disease first described by Rosai and Dorfman in 1969. The typical presentation is that of cervical and often widespread painless lymphadenopathy.
Case report
We present a 33-year-old gentleman, with one-month history of pruritus, abdominal pain, jaundice and dark urine, jaundice, scratch marks, large inguinal lymph nodes, an enlarged liver and spleen. CT scan confirmed ultrasound findings and suggested that splenic lesions were micro-abscesses. Biopsy of the lymph nodes revealed features in keeping with sinus histiocytosis with dermatophatic lymphadenopathy.
Discussion
This is our second case of sinus histiocytosis in two years.
Full Text:
Sinus histiocytosis with massive lymphadenopathy is a rare histiocytic disease first described by Rosai and Dorfman in 1969. The typical presentation is that of cervical and often widespread painless lymphadenopathy.
Case report
We present a 33-year-old gentleman, with one-month history of pruritus, abdominal pain, jaundice and dark urine, jaundice, scratch marks, large inguinal lymph nodes, an enlarged liver and spleen. CT scan confirmed ultrasound findings and suggested that splenic lesions were micro-abscesses. Biopsy of the lymph nodes revealed features in keeping with sinus histiocytosis with dermatophatic lymphadenopathy.
Discussion
This is our second case of sinus histiocytosis in two years.
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