Gastric mucosal status in patients with reflux esophagitis

Riyadh Mohamad Hasan, Batool Mutar Mahdi


Reflux esophagitis and atrophic gastritis has increased in its frequency in patients with dyspepsia, heartburn and regurgitation.

To determine the association of reflux esophagitis, endoscopic gastric mucosal atrophy and histolopathologic atrophy of the gastric mucosa in patients living in Iraq.

A group of 130 consecutive patients who were referred to Gastrointestinal Tract Center at Al-Kindy Teaching Hospital (Baghdad-Iraq) from January 2015 to January 2016. The presence or absence of reflux esophagitis, hiatal hernia and atrophic gastritis were determined by endoscopist. Collected gastric biopsy specimens from those patients were examined by for assessment gastric mucosal status and the presence of atrophic gastritis.

A total of 130 patients were included: 91 men and 39 women, and with mean age of 42.5±6.7 years. According to patients profile, endoscope and histopathological examination of gastric biopsies; there was a significant increase (P=0.0001) in number of patients with diffuse antral gastritis (84(70 per cent)) compared to environmental metaplastic atrophic gastritis (36(30 per cent)). There was a significant increase (P=0.041) in the frequency of reflux esophagitis in patients with diffuse antral gastritis (76.19 per cent) than environmental metaplastic atrophic gastritis (55.55 per cent). There was no significant difference (P=0.479) in the assessment of gastric atrophy between endoscopy or histopathology in patients with reflux esophagitis.

The endoscopic investigation of atrophic gastritis was inversely associated with reflux esophagitis. Endoscopy investigates patients with symptoms of reflux esophagitis because it can confirm or exclude this disease with or without gastric atrophy with certainty.
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