Cross-linking (CXL) is a well-established procedure in children with keratoconus (KC), but cases of CXL and osteogenesis imperfecta (OI) have not been published in the literature, despite the association between physiopathology of these diseases. This is the first case, to the best of our knowledge, of a young girl with both OI and KC that underwent a CXL treatment. In this case, CXL was performed at 6-years-old prior to an expected progression, without complications and probably stopped further keratoconus progression.