Medical training institutions utilize a variety of approaches to present specialty educational material such as radiology. Typically, this material is introduced during the latter years of medical school and includes interactive modules, individual contexts, and case-based learning. This is a quasi-experimental study designed to evaluate the effectiveness of case-based radiology education presented to first-year medical students. Pre- and post-surveys were administered to measure changes in knowledge, perceptions of, and career interest in radiology. The results suggest that the use of case-based learning may improve medical students’ perceived knowledge of radiology and perceived importance of radiologists in the patient care process.