CA 19-9 is more useful than CA 125 in the diagnosis of ovarian malignancy, and can truly differentiate the histological subtypes of the ovarian tumours
Abidullah Khan, Iqbal Haider, Maimoona Ayub, Majid Khan
Abstract
Background
CA 125 is a tumour marker; commonly, used for screening ovarian malignancy. However, recent studies have proven a limited role for CA 125 as a diagnostic marker for ovarian cancer. Nevertheless; recently, a limited number of studies have demonstrated a role for CA 19-9 in the diagnosis and prognosis of malignant ovarian tumours.
Aims
To evaluate the utility of CA 19-9 in the workup of suspected ovarian malignancy.
Methods
In this observational study, on the basis of histopathology reports of ovarian tumours, 45 patients were equally divided into three different groups namely; benign, borderline and malignant. All the patients had their serum CA 125 and CA 19-9 measured preoperatively. The data was analysed using SPSS version 16. One-way ANOVA with Turkey HSD, independent sample t-test and chi squared tests were run for the statistical analysis.
Results
Serum CA 125 does not predict the type of ovarian histopathology in a suspected ovarian malignancy, p>0.05. However, CA 19-9 is the highest in malignant (M=168.27±48.78, p
Full Text:
CA 125 is a tumour marker; commonly, used for screening ovarian malignancy. However, recent studies have proven a limited role for CA 125 as a diagnostic marker for ovarian cancer. Nevertheless; recently, a limited number of studies have demonstrated a role for CA 19-9 in the diagnosis and prognosis of malignant ovarian tumours.
Aims
To evaluate the utility of CA 19-9 in the workup of suspected ovarian malignancy.
Methods
In this observational study, on the basis of histopathology reports of ovarian tumours, 45 patients were equally divided into three different groups namely; benign, borderline and malignant. All the patients had their serum CA 125 and CA 19-9 measured preoperatively. The data was analysed using SPSS version 16. One-way ANOVA with Turkey HSD, independent sample t-test and chi squared tests were run for the statistical analysis.
Results
Serum CA 125 does not predict the type of ovarian histopathology in a suspected ovarian malignancy, p>0.05. However, CA 19-9 is the highest in malignant (M=168.27±48.78, p
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