Background

For eye diseases, such as glaucoma and age-related macular degeneration (ARMD), involved in long-term degeneration procedure, longitudinal comparison of retinal images is a common step for reliable diagnosis of these kinds of diseases.

Aims

To provide a retinal image registration approach for longitudinal retinal image alignment and comparison.

Method

Two image registration solutions were proposed for facing different image qualities of retinal images to make the registration methods more robust and feasible in a clinical application system.

Results

Thirty pairs of longitudinal retinal images were used for the registration test. The experiments showed both solutions provided good performance for the accurate image registrations with efficiency.

Conclusion

We proposed a set of retinal image registration solutions for longitudinal retinal image observation and comparison targeting a clinical application environment.